Table 3 High risk nsSNPs selected by considering ConSurf and PTM predictions.

From: Functional and structural analysis of non-synonymous single nucleotide polymorphisms (nsSNPs) in the MYB oncoproteins associated with human cancer

Protein

SNP ID

Mutation

ConSurf

PTM

Conservation scorea

Prediction

MYB

rs1361650612

G111S

9

e, f

Phosphorylation

rs1179275735

N183S

9

e, f

Phosphorylation

rs1247579811

P574S

9

e, f

Phosphorylation

MYBL1

rs766676175

G122S

9

e, f

Phosphorylation

MYBL2

rs1438994955

S178C

9

e, f

Phosphorylation

  1. b buried residue, s predicted structural residue (highly conserved and buried), e exposed residue, f predicted functional residue (highly conserved and exposed).
  2. aHighly variable (1), highly conserved (9).
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