Figure 1
Landscape of somatic mutations in ALAL by next-generation sequencing. (A) Landscape of mutations detected in acute undifferentiated leukemia (AUL, n = 4), mixed-phenotype acute leukemia (MPAL, n = 13) and cases who were satisfied EGIL but excluded by WHO (n = 2). (B) Landscape of mutations detected in MPAL, including myeloid/B-lymphoid phenotype (MPAL B/M, n = 4), B-lymphoid/T-lymphoid (MPAL B/T, n = 3), and myeloid/T-lymphoid phenotype (MPAL T/M, n = 6). Y-axis represents the ratio of patients with mutations and the patients performed next-generation genetic testing. Columns with different colors represent genes belong to different categories according their attributes. (C) Detailed information of the 17 cases who detected mutations. Each column represents a case and each raw represents a gene. The top bar graph shows the number of mutations detected in each sample. The row directly underneath that graph show the immunophenotypes and Different colors of squares represent various mutation type.
