Figure 5
From: Proteomic mapping of atrial and ventricular heart tissue in patients with aortic valve stenosis
Assessing potentially disease related differences (a) Scatterplot comparing the fold change ratios between atria and ventricles for each protein to the fold change ratios published for healthy hearts by Doll et al. Each point represents a protein. Diagonal line: Deming (Model II) linear regression calculated in GraphPad Prism 9 (Y = 0.9427* X—0.09166). Large dots: Proteins with a distance to the regression line of more than 2 in Y direction. Black: proteins significantly regulated (adj. p < 0.05) in both studies. Pink: significantly regulated in Doll et al.17 but not in this study. Blue: significantly regulated in this study but not in the study of Doll et al. Negative values indicate an upregulation in this study, positive value a regulation towards healthy tissue. (b) Overrepresentation analysis of significantly regulated proteins of this and the study of Doll et al. White: adj. p value > 0.05, light green: adj. p value > 1 × 10–15, green: adj. p value > 1 × 10–50, dark green: adj. p value < 1 × 10–50.
