Table 2 Variants associated with colorectal cancer survival at P < 5 × 10–8, stratified by tumor site.

From: Genome-wide association study identifies tumor anatomical site-specific risk variants for colorectal cancer survival

Chromosome

Variant rsID

Alleles (risk/alternative)

RAF

RegulomeDB rank

HRa

95% CI

P-value

Imputation quality (info score)

Proximal colon

12

rs189655236

C/T

0.014

5

2.14

(1.65, 2.77)

9.19 × 10–09

0.85

14

rs144717887

G/A

0.015

5

2.01

(1.57, 2.58)

3.14 × 10–08

0.93

Distal colon

14

rs698022

C/T

0.111

4

1.48

(1.30, 1.69)

8.47 × 10–09

0.93

  1. Proximal colon tumor-specific analyses included 6,214 cases and distal colon tumor-specific analyses included 4,881 cases.
  2. RAF Risk Allele Frequency, HR Hazard Ratio, CI Confidence Interval. aAdjusted for age at diagnosis, sex, genotyping batch/study, and the first five principal components of genetic ancestry.
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