Figure 1

Scheme of the proposed HNF1B splicing pattern. White boxes represent canonical exons, black lines represent canonical exon-exon junctions. Red boxes represent alternatively spliced exon (E3p) or exon with alternative stop codon (E9*), red lines represent confirmed alternative exon-exon junctions. Gray boxes represent undetermined variant of exon 3 in suggested transcripts. The lengths of the exons are proportional. Amino acid (AA) numbers are indicated below the exon boxes of full-length transcript. The green, grey, blue, and orange areas illustrate the coding areas for functional domains across the HNF1B transcripts. NLS nuclear localization signal (thick blue line). POU_S POU specific domain. POU_H POU homeodomain. The scheme of HNF1B transcripts is based on previous findings¹⁹ and actual RefSeq database information.