Figure 1

Gestational age-dependent changes in the amniotic fluid proteome. (a) The abundance of 1310 proteins was determined by the SOMAmer (Slow Off-rate Modified Aptamers) platform in amniotic fluid samples collected from pregnant women during midtrimester (16–24 weeks, n = 16) and from pregnant women at term without labor (37–42 weeks, n = 14). The figure was created with biorender.com based on the description of SOMAscan assay¹⁰¹. (b) Principal component analysis showing all samples depicted as their first and second principal components derived from the amniotic fluid proteomic data. The proportion of variance explained by each principal component is shown along the axis. The R package, PCAtools, was used to calculate and plot the principal components¹¹⁴. (c) Scatter plot (created in R¹¹⁵) shows the linear correlation between gestational age and the first principal component along with the Pearson correlation coefficient.