Table 2 List of the top 100 amniotic fluid proteins that significantly change in abundance between gestational-age groups in normal pregnancy. The table consists of the gene symbol, protein name, direction of change, and fold change (Term not in labor vs. Midtrimester).
SYMBOL | Name | Direction | Fold |
|---|---|---|---|
LPO | Lactoperoxidase | Up | 266 |
CA6 | Carbonic anhydrase 6 | Up | 137 |
LTF | Lactotransferrin | Up | 115 |
WIF1 | Wnt inhibitory factor 1 | Up | 34.4 |
ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Up | 24.2 |
SPOCK2 | Testican-2 | Up | 22.4 |
AGER | Advanced glycosylation end product-specific receptor, soluble | Up | 21.9 |
CRP | C-reactive protein | Up | 18.6 |
HAMP | Hepcidin | Up | 15.8 |
MPO | Myeloperoxidase | Up | 13.7 |
MMP7 | Matrilysin | Up | 13.3 |
SLPI | Antileukoproteinase | Up | 12.8 |
KLK7 | Kallikrein-7 | Up | 12.8 |
PIGR | Polymeric immunoglobulin receptor | Up | 10.7 |
CTSH | Cathepsin H | Up | 10.7 |
CCL28 | C–C motif chemokine 28 | Up | 9.7 |
EGF | Epidermal growth factor | Up | 8.4 |
LYZ | Lysozyme C | Up | 8.2 |
NTN4 | Netrin-4 | Up | 7.6 |
CTSV | Cathepsin L2 | Up | 7.4 |
TGM3 | Protein-glutamine gamma-glutamyltransferase E | Up | 6.9 |
TFF1 | Trefoil factor 1 | Up | 6.9 |
KLK5 | Kallikrein-5 | Up | 6.1 |
ANK2 | Ankyrin-2 | Up | 5.9 |
CXCL1 | Growth-regulated alpha protein | Up | 5.9 |
KLK11 | Kallikrein-11 | Up | 5.7 |
ARG1 | Arginase-1 | Up | 5.6 |
FAM3D | Protein FAM3D | Up | 5.3 |
S100A9 | Protein S100-A9 | Up | 5.1 |
IL36B | Interleukin-36 beta | Up | 5 |
ANGPT1 | Angiopoietin-1 | Up | 4.9 |
CTSG | Cathepsin G | Up | 4.8 |
APCS | Serum amyloid P-component | Up | 4.7 |
SERPINE1 | Plasminogen activator inhibitor 1 | Up | 4.7 |
CTSS | Cathepsin S | Up | 4.5 |
BPI | Bactericidal permeability-increasing protein | Up | 4.4 |
IL1RN | Interleukin-1 receptor antagonist protein | Up | 4.1 |
MED1 | Mediator of RNA polymerase II transcription subunit 1 | Up | 4.1 |
COLEC12 | Collectin-12 | Up | 3.9 |
CXCL6 | C-X-C motif chemokine 6 | Up | 3.8 |
MIA | Melanoma-derived growth regulatory protein | Up | 3.8 |
CXCL8 | Interleukin-8 | Up | 3.7 |
PDIA3 | Protein disulfide-isomerase A3 | Up | 3.6 |
PGLYRP1 | Peptidoglycan recognition protein 1 | Up | 3.6 |
SCARB2 | Lysosome membrane protein 2 | Up | 3.5 |
GNS | N-acetylglucosamine-6-sulfatase | Up | 3.5 |
ESM1 | Endothelial cell-specific molecule 1 | Up | 3.4 |
TKT | Transketolase | Up | 3.3 |
CHRDL1 | Chordin-like protein 1 | Up | 3.3 |
KLK8 | Kallikrein-8 | Up | 3.3 |
HAPLN1 | Hyaluronan and proteoglycan link protein 1 | Down | 94.7 |
AFP | alpha-Fetoprotein | Down | 25.1 |
LRP1B | Low-density lipoprotein receptor-related protein 1B | Down | 24.1 |
CLEC11A | Stem cell growth factor-alpha | Down | 11.2 |
ENPP7 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 | Down | 9.6 |
FTH1 FTL | Ferritin | Down | 9.3 |
PRSS1 | Trypsin-1 | Down | 9.3 |
DCN | Decorin | Down | 8.2 |
PLA2G7 | Platelet-activating factor acetylhydrolase | Down | 6.8 |
ROBO2 | Roundabout homolog 2 | Down | 6.1 |
SPON1 | Spondin-1 | Down | 5.9 |
TNC | Tenascin | Down | 5.6 |
EFNB2 | Ephrin-B2 | Down | 5.5 |
LAMA1 LAMB1 LAMC1 | Laminin | Down | 5.4 |
MATN2 | Matrilin-2 | Down | 4.9 |
HGF | Hepatocyte growth factor | Down | 4.9 |
SERPINA1 | Alpha-1-antitrypsin | Down | 4.5 |
DKK3 | Dickkopf-related protein 3 | Down | 4.4 |
TGFBI | Transforming growth factor-beta-induced protein ig-h3 | Down | 4.4 |
PGAM1 | Phosphoglycerate mutase 1 | Down | 4.3 |
C1QA C1QB C1QC | Complement C1q subcomponent | Down | 4.1 |
NOTCH3 | Neurogenic locus notch homolog protein 3 | Down | 4 |
PRSS2 | Trypsin-2 | Down | 3.9 |
CD163 | Scavenger receptor cysteine-rich type 1 protein M130 | Down | 3.9 |
LSAMP | Limbic system-associated membrane protein | Down | 3.9 |
CGA CGB | Human Chorionic Gonadotropin | Down | 3.8 |
IGFBP1 | Insulin-like growth factor-binding protein 1 | Down | 3.8 |
LTBP4 | Latent-transforming growth factor beta-binding protein 4 | Down | 3.8 |
EPHA5 | Ephrin type-A receptor 5 | Down | 3.8 |
APOE | Apolipoprotein E (isoform E3) | Down | 3.8 |
MRC2 | C-type mannose receptor 2 | Down | 3.7 |
F10 | Coagulation factor Xa | Down | 3.7 |
TGFBR3 | Transforming growth factor beta receptor type 3 | Down | 3.6 |
ANP32B | Acidic leucine-rich nuclear phosphoprotein 32 family member B | Down | 3.5 |
UNC5D | Netrin receptor UNC5D | Down | 3.5 |
SERPING1 | Plasma protease C1 inhibitor | Down | 3.4 |
MFGE8 | Lactadherin | Down | 3.4 |
TNFRSF21 | Tumor necrosis factor receptor superfamily member 21 | Down | 3.4 |
SPARC | SPARC | Down | 3.4 |
ACY1 | Aminoacylase-1 | Down | 3.4 |
ECM1 | Extracellular matrix protein 1 | Down | 3.4 |
CGA LHB | Luteinizing hormone | Down | 3.3 |
EFNB1 | Ephrin-B1 | Down | 3.2 |
C1R | Complement C1r subcomponent | Down | 3.2 |
NRP1 | Neuropilin-1 | Down | 3.1 |
FN1 | Fibronectin Fragment 3 | Down | 3.1 |
DSC2 | Desmocollin-2 | Down | 3.1 |
APOB | Apolipoprotein B | Down | 3.1 |
SIGLEC14 | Sialic acid-binding Ig-like lectin 14 | Down | 3.1 |
NBL1 | Neuroblastoma suppressor of tumorigenicity 1 | Down | 3 |
