Figure 6 | Scientific Reports

Figure 6

From: O-ring-induced transverse aortic constriction (OTAC) is a new simple method to develop cardiac hypertrophy and heart failure in mice

Figure 6

Histological analysis of left ventricular tissue showing graded cardiac fibrosis. Representative images of short-axis cardiac sections with Sirius-red staining in Sham and OTAC 4 and 8 weeks post procedures (A, B). (A) ×4 magnification of left ventricular at mid-ventricular sections. Scale = 500 µm. (B) Left: ×40 magnification of a representative area of perivascular fibrosis. Scale = 100 µm. (B) Right: ×40 magnification of a representative area of interstitial fibrosis. Scale = 100 µm. (C) Quantification of left ventricular fibrosis (% of the area of mid-ventricular sections) 4 and 8 weeks post procedures. Comparison among groups was performed by one-way ANOVA with Tukey’s post hoc tests; n = 9–14. **P < 0.01.

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