Figure 4 | Scientific Reports

Figure 4

From: CCR2 promotes monocyte recruitment and intestinal inflammation in mice lacking the interleukin-10 receptor

Figure 4

CCR2 facilitates the accumulation of round macrophages within the colon submucosa of IL10RA-deficient mice. (A) Immunofluorescent images from the proximal colon of representative mice of the indicated genotypes showing the localization and morphology of cells staining with Iba1. 20 × magnification, Scale bar indicates 100 μm. The images from IL10RAKO and DKO mice demonstrated a similar density of ramified Iba1-positive cells in the lamina propria (LP) but a reduction in round Iba1-positive cells within the submucosa (SM, filled arrows) of DKO mice compared to IL10RAKO mice. (B) Numbers of Iba1-positive cells in 5 fields from the colon of WT (n = 4), CCR2KO (n = 6), IL10RAKO (n = 12) and DKO (n = 15) mice, as indicated.

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