Figure 3
From: Identification of differentially methylated genes in first-trimester placentas with trisomy 16
The CpG site methylation indices in 5 DMGs in chorionic villi in the group of miscarriages with trisomy 16 compared to miscarriages with trisomy of other chromosomes, miscarriages with a normal karyotype, and induced abortions. (a) The average methylation indices for all analyzed CpG sites in the ANKRD53, GATA3-AS1, CALCB, SCL13A4, and TRPV6 genes in the groups of miscarriages with trisomy 16 (Tri (16)), miscarriages with trisomy of other chromosomes (Tri (non16)), miscarriages with a normal karyotype (NK), and induced abortions (IAs). The line in the center of the box marks the median. The boxes mark the 25th and 75th percentiles. The whiskers extend to the minimum and maximum values. The Mann–Whitney U test was used to compare groups. *—p < 0.05. (b) A detailed profile of the methylation of CpG sites in the analyzed regions of the ANKRD53, GATA3-AS1, SCL13A4, and TRPV6 genes (indicated by a blue shaded area) in the groups of miscarriages with trisomy 16 and miscarriages with trisomy of other chromosomes compared to the induced abortion group. CpG islands are indicated by green bars. The dotted lines depict the standard deviation of the methylation profile. The figure was created using UCSC Genome Browser11.
