Figure 5
Interaction effects between A549 and SF-295 treated with 50 nM TTI-3066. Interaction effects were calculated as ΔSF-295-ΔA549, and genes with |log10(ΔSF-295-ΔA549)|> 2 were included in the heatmap. (A) Heatmap of cells treated for 6 h (outer ring) or 24 h (inner ring). (B) Gene enrichment analysis for PANTHER pathways are included at 6 h and 24 h. Reactome and GO pathway analysis are included in Supplementary Table 4. (C) Representative top pathway hits for the interaction effect at 24 h were determined via GO biological process analysis.
