Table 1 Top 30 hit compounds identified in the ThT screening assay for αSyn fibrillation inhibitors.
From: Two-step screening method to identify α-synuclein aggregation inhibitors for Parkinson’s disease
Compound | Mean lag time (min) n = 3 | ||||
|---|---|---|---|---|---|
0.37 μM | 1.1 μM | 3.3 μM | 10 μM | ||
1 | Tannic acid | 1770 | 2015 | 2505 | 2505 |
2 | Cisplatin | 845 | 845 | 2370 | 2505 |
3 | Apomorphine hydrochloride | 1245 | 1980 | 2330 | 2505 |
4 | Norepinephrine | 1125 | 1530 | 2040 | 2505 |
5 | Diflunisal | 1730 | 1850 | 1965 | 2505 |
6 | Rabeprazole sodium | 985 | 1665 | 2015 | 2500 |
7 | Althiazide | 1120 | 1555 | 1780 | 2200 |
8 | Dopamine hydrochloride | 1065 | 1295 | 1620 | 2085 |
9 | Hymechrome | 1800 | 1705 | 1820 | 2070 |
10 | Pantoprazole | 950 | 1215 | 1785 | 2070 |
11 | Tamoxifen citrate | 1255 | 1305 | 1515 | 2070 |
12 | Donepezil hydrochloride | 1345 | 1340 | 1560 | 2030 |
13 | Hyoscyamine | 1405 | 1450 | 2195 | 2010 |
14 | Glucosamine hydrochloride | 1190 | 1760 | 2095 | 1925 |
15 | Methyldopa | 1440 | 1415 | 1240 | 1925 |
16 | Chlorophyllide Cu complex Na salt | 820 | 930 | 1000 | 1920 |
17 | Isotretinoin | 1495 | 1485 | 2050 | 1885 |
18 | Pirenperone | 1355 | 1450 | 1865 | 1845 |
19 | Entacapone | 1385 | 1695 | 1830 | 1800 |
20 | Nisoldipine | 1285 | 1450 | 1490 | 1795 |
21 | Chloroxine | 1345 | 1445 | 1875 | 1785 |
22 | Paroxetine hydrochloride | 1330 | 1385 | 1620 | 1705 |
23 | Risedronate sodium | 1260 | 1520 | 1640 | 1700 |
24 | Nateglinide | 955 | 1370 | 1360 | 1630 |
25 | Diethylcarbamazine citrate | 1060 | 1350 | 1470 | 1625 |
26 | Deferoxamine mesylate | 1260 | 1335 | 1255 | 1580 |
27 | Fenoldopam mesylate | 1120 | 1180 | 1390 | 1400 |
28 | Oxidopamine hydrochloride | 1045 | 1055 | 1125 | 1365 |
29 | Oxyquinoline sulfate | 575 | 725 | 815 | 1060 |
30 | Neomycin sulfate | 670 | 815 | 810 | 980 |
