Table 2 List of top 10 up- and down-regulated genes in active vs atrophic pterygium and their associated biological processes.
From: Transcriptomics and network analysis highlight potential pathways in the pathogenesis of pterygium
DE | Fold change | p value | AUC | Main biological process |
|---|---|---|---|---|
Up-regulated | ||||
CXCL9 | 126.36 | 0.0003 | 0.86 | Immune and inflammatory response |
TYRP1 | 8.76 | 0.0065 | 0.86 | Aldosterone synthesis and secretion |
SERPINB5 | 7.29 | 0.0002 | 1.00 | Angiogenesis |
BMP4 | 7.04 | 0.0006 | 1.00 | Degradation of the extracellular matrix |
TYR | 6.95 | 0.0006 | 1.00 | (S)-reticuline biosynthesis and Tyrosine metabolism |
PIM1 | 6.78 | 0.0075 | 0.93 | Cell growth. differentiation and apoptosis |
VSNL1 | 6.28 | 0.0016 | 1.00 | Modulation of intracellular signaling pathways |
MLANA | 5.64 | 0.0007 | 1.00 | NF-kappaB Signaling |
PLA2G2D | 5.44 | 0.0043 | 0.71 | Targets extracellular lipids; anti-inflammatory and immunosuppressive functions |
DSG1 | 5.35 | 0.0002 | 1.00 | Keratinization |
Down-regulated | ||||
CIART | 0.03 | 0.0032 | 1.00 | Circadian rythm |
AQP9 | 0.16 | 0.0001 | 1.00 | Transporter activity and glycerol channel activity |
LINC01001 | 0.17 | 0.0091 | 1.00 | * |
mir1279 | 0.18 | 0.0005 | 1.00 | # |
CXCL6 | 0.18 | 0.0027 | 1.00 | Chemotactic and angiogenic properties |
TEF | 0.19 | 0.0083 | 1.00 | Circadian rythm |
TREM1 | 0.21 | 0.0024 | 1.00 | Cell surface interactions at the vascular wall |
COL6A3 | 0.22 | 0.0025 | 1.00 | Integrin Pathway and Collagen chain trimerization |
mir604 | 0.23 | 0.0009 | 1.00 | # |
NEURL4 | 0.23 | 0.0004 | 1.00 | Ubiquitination and proteasome-dependent degradation |
