Table 1 Baseline characteristics.

Parameters	eRFA + CT (n = 40)	CT (n = 26)	P-value
Age [years]	69.0 (57.5; 76.8)	66.5 (57.0; 72.0)	0.187
Gender			0.522
Male	23 (57.5)	17 (65.4)
Female	17 (42.5)	9 (34.6)
Tumor localization			0.682
Bismuth 1–2 and distal CCA	9 (22.5)	7 (26.9)
Bismuth 3–4	31 (77.5)	19 (73.1)
M status			0.315
M0	25 (62.5)	13 (50.0)
M1	15 (37.5)	13 (50.0)
Grading			0.357
G1	8 (20.0)	2 (7.7)
G2	17 (42.5)	9 (34.6)
G3	9 (22.5)	9 (34.6)
G4	1 (2.5)	0 (0)
ECOG			0.755
0	23 (57.5)	15 (57.7)
1	10 (25.0)	8 (30.8)
2	7 (17.5)	3 (11.5)
CA 19–9 [U/ml]	207 (32; 758)	330 (80; 2263)	0.194
CEA [ng/ml]	3.1 (2.0; 5.7)	2.9 (1.8; 27.0)	0.708
Total bilirubin [mg/dl]	1.8 (0.7; 5.4)	1.0 (0.5; 2.0)	0.061
gGT [U/l]	720 (313; 1188)	396 (210; 980)	0.358
Aspartate aminotransferase [U/l]	67 (44; 145)	49 (33; 88)	0.121
Alanine aminotransferase [U/l]	70 (37; 125)	81 (40; 120)	0.990
Alkaline phosphatase [U/l]	471 (258; 630)	385 (187; 266)	0.325
INR [U/l]	1.0 (1.0; 1.1)	1.0 (1.0; 1.0)	0.095
MELD score	10.1 (7.0; 13.8)	6.7 (6.4; 9.8)	0.015
Creatinine [mg/dl]	0.8 (0.7; 1.0)	0.7 (0.6; 0.9)	0.227
CRP [mg/l]	17.7 (9.8; 55.9)	14.1 (3.9; 35.9)	0.287
Neutrophiles [/nl]	6.0 (3.7; 8.6)	4.6 (3.4; 6.7)	0.069
Lymphocytes [/nl]	1.4 (1.0; 1.9)	1.3 (0.9; 1.8)	0.660
Blood neutrophil to lymphocyte ratio	4.8 (2.3; 7.5)	4.1 (2.6; 5.1)	0.454

Categorical data are presented as absolute frequency with relative frequency in parentheses. Numerical data are presented as median with under and upper quartile in parentheses.
P values of categorical data refer to Chi-squared test or Fisher exact test between groups eRFA + CT and CT. P values of numerical data refer to Student unpaired t test or Mann–Whitney test between groups eRFA + CT and CT.
CA19-9 carbohydrate antigen 19-9, CCA cholangiocarcinoma, CEA carcinoembryonic antigen, CRP C-reactive protein, ECOG Eastern Cooperative Oncology Group performance status, gGT gamma-glutamyltransferase, INR international normalized ratio.

Search