Figure 1
From: Mitochondrial function influences expression of methamphetamine-induced behavioral sensitization
Study timelines. (a) Alzet® minipumps set to deliver vehicle, 1 mg/kg/day or 3 mg/kg/day of rotenone were implanted subcutaneously. Behavioral measures were conducted on days 1, 3 and 6 of treatment. Pumps were then removed and tissues were harvested at the end of treatment day 6. (b) Rats self-administered meth 3 h/day for 14 days via lever pressing or were non-contingently given meth via subcutaneous injection. Alzet® minipumps containing vehicle or 1 mg/kg/day of rotenone were implanted subcutaneously on meth forced abstinence day 0, 14, or 28. Pumps were then removed and tissues were harvested at the end of treatment day 6. Rats abstained from all treatment until forced abstinence day 61, which is when all rats were subcutaneously administered 1 mg/kg meth (meth acute challenge) and behavioral measures were collected. On forced abstinence day 62, rats were sacrificed and tissues were collected.
