Table 4 Onset phase motor effects.
From: Mitochondrial function influences expression of methamphetamine-induced behavioral sensitization
Onset phase of responding to acute meth challenge | ||||||
|---|---|---|---|---|---|---|
Two-way ANOVA | Between-time Post Hoc within operant treatments | Within-time Post Hoc between operant treatments | ||||
Saline/rotenone vs saline/rotenone | Meth/rotenone vs meth/rotenone | Saline/rotenone vs meth/rotenone | ||||
Horizontal beam breaks | Time: F(2, 43) = 11.8, p < 0.01 Treatment: F(1, 43) = 0.9, p \(\ge\) 0.05 Interaction: F(2, 43) = 9.4, p < 0.01 | R0 vs R14 R0 vs R28 R14 vs R28 | p \(\ge\) 0.05 p < 0.01 p < 0.01 | p < 0.01 p \(\ge\) 0.05 p < 0.01 | R0 R14 R28 | p \(<\) 0.01 p \(\ge\) 0.05 p \(\ge\) 0.05 |
Total distance traveled | Time: F(2, 43) = 1.4, p < 0.01 Treatment: F(1, 43) = 1.7, p \(\ge\) 0.05 Interaction: F(2, 43) = 5.2, p < 0.01 | R0 vs R14 R0 vs R28 R14 vs R28 | p \(\ge\) 0.05 p \(\ge\) 0.05 p \(\ge\) 0.05 | p < 0.05 p \(\ge\) 0.05 p \(\ge\) 0.05 | R0 R14 R28 | p \(<\) 0.01 p \(\ge\) 0.05 p \(\ge\) 0.05 |
Vertical beam breaks | Time: F(2, 43) = 0.4, p \(\ge\) 0.05 Treatment: F(1, 43) = 8.9, p < 0.01 Interaction: F(2, 43) = 0.4, p \(\ge\) 0.5 | R0 vs R14 R0 vs R28 R14 vs R28 | p \(\ge\) 0.05 p < 0.05 p < 0.05 | p \(\ge\) 0.05 p \(\ge\) 0.05 p \(\ge\) 0.05 | R0 R14 R28 | p \(\ge\) 0.05 p \(\ge\) 0.05 p \(\ge\) 0.05 |
Vertical time | Time: F(2, 43) = 6.9, p < 0.01 Treatment: F(1, 43) = 0.9, p \(\ge\) 0.05 Interaction: F(2, 43) = 0.2, p \(\ge\) 0.05 | R0 vs R14 R0 vs R28 R14 vs R28 | p \(\ge\) 0.05 p < 0.05 p < 0.05 | p \(\ge\) 0.05 p \(\ge\) 0.05 p \(\ge\) 0.05 | R0 R14 R28 | p \(\ge\) 0.05 p \(\ge\) 0.05 p \(\ge\) 0.05 |
Vertical movement number | Time: F(2, 43) = 16.2, p < 0.01 Treatment: F(1, 43) = 0.1, p \(\ge\) 0.05 Interaction: F(2, 43) = 0.7, p \(\ge\) 0.05 | R0 vs R14 R0 vs R28 R14 vs R28 | p < 0.05 p < 0.01 p < 0.05 | p \(\ge\) 0.05 p < 0.01 p < 0.05 | R0 R14 R28 | p \(\ge\) 0.05 p \(\ge\) 0.05 p \(\ge\) 0.05 |
Stereotypy count | Time: F(2, 43) = 10.4, p < 0.01 Treatment: F(1, 43) = 0.01, p \(\ge\) 0.05 Interaction: F(2, 43) = 5.6, p < 0.01 | R0 vs R14 R0 vs R28 R14 vs R28 | p \(\ge\) 0.05 p < 0.01 p < 0.05 | p < 0.05 p < 0.05 p < 0.05 | R0 R14 R28 | p \(<\) 0.05 p \(\ge\) 0.05 p \(\ge\) 0.05 |
stereotypy time | Time: F(2, 43) = 7.4, p < 0.01 Treatment: F(1, 43) = 0.004, p \(\ge\) 0.05 Interaction: F(2, 43) = 4.7, p < 0.05 | R0 vs R14 R0 vs R28 R14 vs R28 | p \(\ge\) 0.05 p < 0.01 p < 0.05 | p \(\ge\) 0.05 p \(\ge\) 0.05 p \(\ge\) 0.05 | R0 R14 R28 | p \(\ge\) 0.05 p \(\ge\) 0.05 p \(\ge\) 0.05 |
Stereotypy number | Time: F(2, 43) = 5.7, p < 0.01 Meth: F(1, 43) = 0.6, p \(\ge\) 0.05 Interaction: F(2, 43) = 1.7, p \(\ge\) 0.05 | R0 vs R14 R0 vs R28 R14 vs R28 | p \(\ge\) 0.05 p \(\ge\) 0.05 p \(\ge\) 0.05 | p \(\ge\) 0.05 p \(\ge\) 0.05 p \(\ge\) 0.05 | R0 R14 R28 | p \(\ge\) 0.05 p \(\ge\) 0.05 p \(\ge\) 0.05 |
