Table 5 Peak phase motor effects.
From: Mitochondrial function influences expression of methamphetamine-induced behavioral sensitization
Peak phase of responding to acute meth challenge | ||||||
|---|---|---|---|---|---|---|
Two-Way ANOVA | Between-time post hoc within operant treatments | Within-time post hoc between operant treatments | ||||
Saline/rotenone vs saline/rotenone | Meth/rotenone vs mth/rotenone | Saline/rotenone vs meth/rotenone | ||||
Horizontal beam breaks | Time: F(2, 43) = 18.8, p < 0.01 Treatment: F(1, 43) = 5.6, p \(\ge\) 0.05 Interaction: F(2, 43) = 10.6, p < 0.01 | R0 vs R14 R0 vs R28 R14 vs R28 | p \(\ge\) 0.05 p < 0.01 p < 0.01 | p < 0.01 p \(\ge\) 0.05 p < 0.05 | R0 R14 R28 | p \(<\) 0.01 p \(\ge\) 0.05 p \(\ge\) 0.05 |
Total distance traveled | Time: F(2, 43) = 13.6, p < 0.01 Treatment: F(1, 43) = 6.4, p < 0.05 Interaction: F(2, 43) = 13.7, p < 0.01 | R0 vs R14 R0 vs R28 R14 vs R28 | p < 0.05 p < 0.01 p < 0.01 | p < 0.01 p \(\ge\) 0.05 p < 0.05 | R0 R14 R28 | p \(<\) 0.01 p \(\ge\) 0.05 p \(\ge\) 0.05 |
Vertical beam breaks | Time: F(2, 43) = 35.9, p < 0.01 Treatment: F(1, 43) = 0.4, p \(\ge\) 0.05 Interaction: F(2, 43) = 5.7, p < 0.01 | R0 vs R14 R0 vs R28 R14 vs R28 | p < 0.01 p < 0.01 p < 0.01 | p \(\ge\) 0.05 p < 0.01 p < 0.01 | R0 R14 R28 | p \(<\) 0.01 p \(\ge\) 0.05 p \(\ge\) 0.05 |
Vertical time | Time: F(2, 43) = 29.2, p < 0.01 Treatment: F(1, 43) = 1.3, p \(\ge\) 0.05 Interaction: F(2, 43) = 3.1, p < 0.05 | R0 vs R14 R0 vs R28 R14 vs R28 | p < 0.01 p < 0.01 p < 0.01 | p \(\ge\) 0.05 p < 0.01 p < 0.01 | R0 R14 R28 | p \(<\) 0.05 p \(<\) 0.05 p \(\ge\) 0.05 |
Vertical movement number | Time: F(2, 43) = 56.5, p < 0.01 Treatment: F(1, 43) = 1.3, p \(\ge\) 0.05 Interaction: F(2, 43) = 3.4, p < 0.05 | R0 vs R14 R0 vs R28 R14 vs R28 | p < 0.01 p < 0.01 p < 0.01 | p \(\ge\) 0.05 p < 0.01 p < 0.01 | R0 R14 R28 | p \(<\) 0.01 p \(\ge\) 0.05 p \(\ge\) 0.05 |
Stereotypy count | Time: F(2, 43) = 6.2, p < 0.01 Treatment: F(1, 43) = 1.3, p \(\ge\) 0.05 Interaction: F(2, 43) = 3.4, p < 0.05 | R0 vs R14 R0 vs R28 R14 vs R28 | p \(\ge\) 0.05 p \(\ge\) 0.05 p \(\ge\) 0.05 | p \(\ge\) 0.05 p \(\ge\) 0.05 p \(\ge\) 0.05 | R0 R14 R28 | p \(<\) 0.05 p \(\ge\) 0.05 p \(\ge\) 0.05 |
Stereotypy time | Time: F(2, 43) = 0.3, p > 0.05 Treatment: F(1, 43) = 0.4, p \(\ge\) 0.05 Interaction: F(2, 43) = 0.5, p > 0.05 | R0 vs R14 R0 vs R28 R14 vs R28 | p \(\ge\) 0.05 p \(\ge\) 0.05 p \(\ge\) 0.05 | p \(\ge\) 0.05 p \(\ge\) 0.05 p \(\ge\) 0.05 | R0 R14 R28 | p \(\ge\) 0.05 p \(\ge\) 0.05 p \(\ge\) 0.05 |
Stereotypy number | Time: F(2, 43) = 0.5, p \(\ge\) 0.05 Treatment: F(1, 43) = 2.0, p \(\ge\) 0.05 Interaction: F(2, 43) = 3.3, p \(\ge\) 0.05 | R0 vs R14 R0 vs R28 R14 vs R28 | p \(\ge\) 0.05 p \(\ge\) 0.05 p \(\ge\) 0.05 | p \(\ge\) 0.05 p \(\ge\) 0.05 p \(\ge\) 0.05 | R0 R14 R28 | p \(\ge\) 0.05 p \(\ge\) 0.05 p \(\ge\) 0.05 |
