Figure 1 | Scientific Reports

Figure 1

From: Transcriptomes of peripheral blood mononuclear cells from juvenile dermatomyositis patients show elevated inflammation even when clinically inactive

Figure 1

Untreated JDM has an enrichment of type 1 interferon signaling. (a) Volcano plot for samples from untreated JDM patients versus controls. The x-axis shows the log2 fold-change, and the y-axis shows the false-discovery rate corrected p value. The two vertical lines indicate the cutoff points for a 1.5-fold change. The horizontal line indicates the 0.05 adjusted p value cutoff. Some of the most significant genes are individually labeled. Insignificant points are colored gray. Significant points are labeled red or blue depending on whether the fold-change met a 1.5-fold threshold. There are some significantly decreased genes, but by far the most significant changes are increases in inflammatory genes, specifically interferon signaling. (b) Significantly enriched pathways for genes with increased in untreated JDM from gProfileR. There are enrichments interferon signaling, cytokines, chemokines, and IL-10.

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