Figure 9 | Scientific Reports

Figure 9

From: Transcriptomes of peripheral blood mononuclear cells from juvenile dermatomyositis patients show elevated inflammation even when clinically inactive

Figure 9

JDM skin has a strong signal for decreased translation and protein targeting, with enrichments for increased type 1 interferon signaling. (a) JDM versus control skin volcano plot. The x-axis is log2 fold-change and the y-axis is -log10 of false-discovery rate corrected p value. The horizontal dashed line is the 0.05 significance cutoff, and the vertical dashed lines are minimum 1.5-fold changes. (b) gProfileR enrichments for genes with decreased expression are enriched for translation and protein localization. (c) Genes increased in JDM skin have a strong type 1 interferon signature.

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