Table 1 Clinical and demographic characteristics of KF patients and controls.
From: Longitudinal genome-wide DNA methylation changes in response to kidney failure replacement therapy
Controls | Kidney transplantation group | Kidney transplantation group | Incident dialysis group | Incident dialysis group | p-value | |
|---|---|---|---|---|---|---|
Baseline | Baseline | 1 year | Baseline | 1 year | ||
N = 24 | N = 12 | N = 12 | N = 11 | N = 11 | ||
Clinical characteristics | ||||||
Age (years) | 51.5 (46.5–56.0) | 48.0 (44.5–50.0) | 49.0 (45.5–51.0) | 48.0 (43.0–54.0) | 49.0 (44.0–55.0) | 0.27 |
Males, n (%) | 14 (58%) | 7 (58%) | 7 (58%) | 8 (73%) | 8 (73%) | 0.85 |
Diabetes mellitus, n (%) | 0 (0%) | 3 (25%) | 3 (25%) | 3 (27%) | 3 (27%) | 0.12 |
Cardiovascular disease, n (%) | 0 (0%) | 3 (25%) | na | 3 (27%) | 3 (27%) | 0.043 |
eGFRa (ml/min/1.73m2) | 93.2 (80.3–105.4) | 6.6 (5.7–8.2) | 62.7 (44.9–74.3) | 5.0 (3.9–9.0) | na | < 0.001 |
BMI (kg/m2) | 23.7 (22.3–27.0) | 23.8 (20.2–29.8) | 24.6 (22.0–27.4) | 25.5 (22.0–26.4) | 26.0 (22.9–27.7) | 0.61 |
Biochemical characteristics | ||||||
Albumin (g/l) | 40 (38–42) | 36 (34–37) | 36 (34–39) | 34 (32–40) | 35 (34–40) | 0.003 |
Creatinine (µmol/l) | 75 (69–87) | 680 (529–858) | 117 (90–143) | 742 (591–955) | 761 (658–871) | < 0.001 |
Haemoglobin (g/l) | na | 116 (105–126) | 139 (129–145) | 117 (101–126) | 110 (106–126) | 0.001 |
Total Cholesterol (mmol/l) | 5.1 (4.5–5.8) | 4.8 (4.4–6.3) | 6.0 (4.8–7.7) | 4.3 (4.0–5.2) | 4.4 (4.1–5.3) | 0.007 |
HDL-cholesterol (mmol/l) | na | 1.3 (1.1–1.4) | 1.2 (1.1–1.5) | 1.5 (1.4–1.8) | 1.5 (1.2–1.7) | 0.11 |
Triglyceride (mmol/l) | 1.0 (0.7–1.7) | 1.8 (1.5–2.6) | 2.6 (1.5–4.0) | 1.5 (1.2–1.9) | 1.6 (1.1–2.9) | 0.022 |
IL-6 (pg/ml) | 1.2 (0.7–3.4) | 1.0 (0.8–1.3) | na | 5.0 (3.7–9.5) | 9.7 (4.4–14.9) | < 0.001 |
hsCRP (mg/l) | 0.6 (0.4–1.7) | 1.0 (0.2–3.5) | 1.4 (0.8–9.5) | 1.8 (1.0–4.5) | 2.0 (1.0–2.7) | 0.095 |
Leucocytes, (109/l) | 5.7 (4.7–7.0) | 8.8 (6.5–10.5) | 7.1 (6.0–7.4) | 7.5 (4.1–8.0) | 6.6 (4.7–7.6) | 0.022 |
Thrombocytes, (109/l) | 257 (229–293) | 240 (232–265) | 211 (168–253) | 238 (143–297) | 263 (137–311) | 0.70 |
Neutrophils, (109/l) | 2.8 (2.2–4.0) | 6.7 (3.6–9.0) | 4.4 (3.4–6.2) | 4.1 (2.6–5.4) | 3.2 (2.0–4.4) | 0.002 |
Eosinophils, (109/l) | 0.3 (0.2–0.4) | 0.1 (0.1–0.2) | 0.1 (0.1–0.1) | 0.3 (0.2–0.5) | 0.2 (0.1–0.3) | 0.002 |
Basophils, (109/l) | 0.04 (0.03–0.06) | 0.1 (0.1–0.1) | 0.1 (0.1–0.1) | 0.1 (0.04–0.1) | 0.1 (0.1–0.1) | < 0.001 |
Lymphocytes, (109/l) | 2.2 (1.7–2.7) | 1.2 (1.0–1.4) | 1.3 (0.9–2.0) | 1.8 (0.9–2.1) | 1.4 (0.9–2.0) | 0.002 |
Monocytes, (109/l) | 0.3 (0.3–0.4) | 0.6 (0.4–0.8) | 0.7 (0.5–0.9) | 0.5 (0.3–0.6) | 0.4 (0.3–0.6) | < 0.001 |
