Table 3 Genes with the highest number of statistically significant probes (FDR < 0.01).
From: Longitudinal genome-wide DNA methylation changes in response to kidney failure replacement therapy
Gene symbol | CpG sites | PFDR range | FC range | |
|---|---|---|---|---|
Controls vs dialysis baseline | SKI | 11 | 1.5 × 10–4 to 9.7 × 10–3 | 0.21–4.07 |
PRDM16 | 10 | 6.6 × 10–4 to 8.7 × 10–3 | 0.21–2.51 | |
TRIM26 | 8 | 2.5 × 10–4 to 8.8 × 10–3 | 0.19–5.75 | |
HDAC4 | 8 | 2.8 × 10–4 to 9.8 × 10–3 | 0.19–12.88 | |
ZMIZ1 | 7 | 2.6 × 10–4 to 9.2 × 10–3 | 0.2–0.58 | |
LOC146880 | 7 | 3.2 × 10–4 to 9.8 × 10–3 | 0.17–0.5 | |
GFI1 | 7 | 1.1 × 10–4 to 8 × 10–3 | 0.08–0.24 | |
HIVEP3 | 7 | 1.7 × 10–4 to 8.1 × 10–3 | 0.05–2.82 | |
BAHCC1 | 7 | 7 × 10–4 to 8.7 × 10–3 | 0.32–0.46 | |
Controls vs dialysis 12 months | MAD1L1 | 5 | 5.4 × 10–4 to 7.5 × 10–3 | 0.26–0.42 |
MYL9 | 4 | 2.9 × 10–3 to 6.1 × 10–3 | 0.25–0.37 | |
LOC284837 | 4 | 4.6 × 10–4 to 3.5 × 10–3 | 0.33–0.45 | |
SKI | 3 | 1 × 10–3 to 8.9 × 10–3 | 0.28–3.8 | |
PTPRCAP | 3 | 6.7 × 10–3 to 7.2 × 10–3 | 1.86–2.82 | |
PRDM16 | 3 | 2.6 × 10–3 to 5.9 × 10–3 | 0.32–0.47 | |
MRFAP1 | 3 | 7.1 × 10–4 to 6.6 × 10–3 | 2.69–38.9 | |
RPS11 | 3 | 3.3 × 10–3 to 6 × 10–3 | 3.63–17.78 | |
FANCF | 3 | 2.9 × 10–3 to 8.4 × 10–3 | 2.51–3.39 | |
HDAC4 | 3 | 1.3 × 10–4 to 4.4 × 10–3 | 2.57–5.5 | |
C17orf64 | 3 | 8.8 × 10–4 to 9.7 × 10–3 | 0.19–0.46 | |
Controls vs KTx baseline | MAD1L1 | 34 | 4.6 × 10–7 to 9.2 × 10–3 | 0.11–22.91 |
HDAC4 | 29 | 6.4 × 10–6 to 8.9 × 10–3 | 0.07–14.45 | |
RPTOR | 28 | 1.2 × 10–6 to 5.1 × 10–3 | 0.07–9.77 | |
TBCD | 26 | 1.5 × 10–6 to 7.4 × 10–3 | 0.05–21.38 | |
NCOR2 | 26 | 1.5 × 10–6 to 8.4 × 10–3 | 0.07–2.69 | |
RASA3 | 22 | 4.8 × 10–7 to 9.1 × 10–3 | 0.05–9.12 | |
KCNQ1 | 20 | 4.1 × 10–6 to 9.7 × 10–3 | 0.15–18.62 | |
ANKRD11 | 19 | 4.4 × 10–7 to 8.9 × 10–3 | 0.09–7.41 | |
BCL11B | 18 | 4.7 × 10–7 to 2.7 × 10–3 | 0.3–35.48 | |
Controls vs KTx 12 months | RASA3 | 11 | 2.9 × 10–4 to 9.5 × 10–3 | 0.09–5.62 |
MAD1L1 | 11 | 6.9 × 10–4 to 9.8 × 10–3 | 0.2–10.23 | |
TBCD | 9 | 4.9 × 10–4 to 9.2 × 10–3 | 0.13–4.79 | |
RPTOR | 9 | 7.3 × 10–4 to 9.2 × 10–3 | 0.15–3.89 | |
DDR1 | 8 | 3.3 × 10–4 to 7.1 × 10–3 | 1.78–5.37 | |
BANP | 8 | 2.4 × 10–4 to 6.2 × 10–3 | 0.19–5.89 | |
ARID3A | 8 | 9 × 10–4 to 8.8 × 10–3 | 0.06–0.32 | |
FOXK1 | 7 | 4.8 × 10–3 to 9.3 × 10–3 | 0.12–2.95 | |
ITPKB | 7 | 6.9 × 10–4 to 9.6 × 10–3 | 0.32–6.31 | |
HDAC4 | 7 | 6.5 × 10–4 to 4.4 × 10–3 | 0.19–10.23 |
