Figure 6
From: The rexinoid V-125 reduces tumor growth in preclinical models of breast and lung cancer
V-125 differentially regulates cancer-associated genes in tumors. Mice with established mammary tumors 5 mm in diameter were treated with control or V-125 (100 mg/kg in diet) for 10 days. Total RNA was extracted for PCR array. Analysis was performed using GeneGlobe software (Qiagen), revealing the upregulation of 10 genes with a log fold change > 2 (A), and the downregulation of 10 genes with a log fold change > 2 (B). Validation was performed on IL-6 (C), Jun (D), and COX2 (E) by qPCR. N = 2 mice/group. Data shown is representative of two independent experimental runs.
