Table 2 Effect of adjustments on the association between selected lipids and blood pressure.
From: A multi-omics study of circulating phospholipid markers of blood pressure
Name | Model 1 | Model 2 | ||||||
|---|---|---|---|---|---|---|---|---|
Discovery (N = 2786) | Replication (N = 1185) | Combined (N = 3971) | Combined (N = 3937) | |||||
Effect | P-value | Effect | P-value | Effect | P-value | Effect | P-value | |
Systolic blood pressure | ||||||||
PC 32:1 | 2.7 | 1.5 × 10−06 | 1.8 | 2.4 × 10−04 | 2.2 | 2.6 × 10−09 | 2.1 | 9.6 × 10−08 |
PC 40:5 | 2.0 | 6.7 × 10−04 | 2.0 | 1.0 × 10−04 | 2.2 | 3.2 × 10−09 | 1.6 | 2.7 × 10−05 |
PE 38:3 | 2.1 | 7.0 × 10−05 | 2.2 | 2.6 × 10−05 | 2.1 | 6.8 × 10−09 | 1.5 | 4.0 × 10−05 |
PE 40:5 | 2.1 | 4.9 × 10−05 | 2.3 | 1.7 × 10−05 | 2.2 | 3.2 × 10−09 | 1.6 | 2.7 × 10−05 |
PE 40:6 | 2.4 | 2.2 × 10−05 | 1.7 | 6.7 × 10−04 | 2.0 | 8.6 × 10−08 | 1.2 | 1.9 × 10−03 |
Diastolic blood pressure | ||||||||
PE 38:4 | 1.5 | 9.7 × 10−06 | 1.2 | 7.6 × 10−07 | 1.3 | 3.7 × 10−11 | 0.9 | 1.3 × 10−05 |
PE 40:5 | 1.3 | 1.4 × 10−05 | 1.4 | 6.7 × 10−08 | 1.4 | 3.5 × 10−12 | 1.0 | 3.4 × 10−06 |
PE 40:6 | 1.4 | 4.4 × 10−05 | 1.3 | 3.5 × 10−07 | 1.3 | 5.7 × 10−11 | 0.7 | 3.4 × 10−04 |
PE 38:3 | 1.1 | 3.0 × 10−04 | 1.3 | 1.8 × 10−07 | 1.2 | 7.0 × 10−10 | 0.8 | 4.0 × 10−05 |
PE 38:6 | 1.1 | 6.5 × 10−04 | 0.8 | 2.5 × 10−03 | 0.9 | 1.2 × 10−05 | 0.6 | 2.7 × 10−03 |
PE 40:4 | 1.1 | 3.9 × 10−04 | 1.9 | 3.1 × 10−11 | 1.6 | 3.8 × 10−13 | 1.2 | 7.2 × 10−08 |
