Table 4 Brain morphometric characteristics and lesions.

From: Cortical morphology predicts placebo response in multiple sclerosis

Measure (SD)

Non-responder (n = 45)

Responder (n = 43)

p

New T2 lesions (# of patients with lesion count)

W24

W48

W24

W48

0

36

36

35

33

< 0.001**

1

4

5

3

4

2

3

0

1

3

3

0

2

0

1

5

1

0

0

0

6

0

0

1

0

7

0

0

0

1

8

0

0

2

0

9

0

0

1

0

11

0

0

0

1

Unique newly active lesions (# of patients with lesion count)

BL

W24

W48

BL

W24

W48

 

0

40

33

36

33

34

33

< 0.0005***

1

1

6

5

3

2

3

2

3

4

0

2

2

3

3

0

0

1

2

1

1

4

0

0

0

1

0

0

5

0

0

1

0

0

0

6

0

1

0

0

1

1

7

0

0

0

1

0

0

8

0

0

0

0

1

1

11

0

0

0

0

0

1

15

0

0

0

0

1

0

22

0

0

0

0

1

0

Newly enhancing lesions (# of patients with lesion count)

BL

W24

W48

BL

W24

W48

 

0

40

36

38

33

36

34

< 0.01*

1

1

6

4

3

4

5

2

3

2

1

2

0

0

3

0

0

0

2

1

2

4

0

0

0

1

0

0

5

0

0

0

0

0

2

6

0

0

0

0

1

0

7

0

0

0

1

0

0

Newly enlarging T2 lesions (# of patients with lesion count)

W24

W48

W24

W48

 

0

42

42

38

38

W24: 0.0005***

W48: 0.14

1

2

0

2

4

2

0

1

1

1

7

0

0

1

0

13

0

0

1

0

  1. BL = Baseline; W24 = 24 weeks assessment point; W48 = 48 weeks assessment point; WM = white mater. P values represent comparisons between placebo responders and non-responders for corresponding assessment points. The models include age, sex, age x sex interaction, disease duration and site as terms.
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