Table 5 Regions where cortical thickness was predicted by lesion load in placebo non-responders.

From: Cortical morphology predicts placebo response in multiple sclerosis

Cluster

# Vertices

Peak

x

y

z

t

p

Right superior and medial frontoparietal

p < 0.00005

4080

Medial frontal gyrus (R)

4.30

− 24.62

57.64

5.22

0.008

Superior parietal lobule (R)

28.69

− 57.71

52.84

5.03

0.013

Precuneus (R)

13.35

− 66.54

32.83

4.96

0.015

Middle occipital gyrus (R)

44.45

 − 77.33

22.46

4.83

0.021

Postcentral gyrus (R)

11.82

− 59.08

69.79

4.75

0.027

Paracentral lobule (R)

13.69

− 41.22

58.15

4.56

0.043

Right precentral gyrus/insula

p < 0.00005

3026

Precentral gyrus (R)

52.78

− 6.92

10.30

5.32

0.006

Insula (R)

39.91

− 0.08

16.26

5.21

0.008

Left parahippocampal gyrus

p < 0.00005

383

Parahippocampal gyrus (L)

− 12.13

− 9.54

− 12.02

5.41

0.005

Right inferior temporal gyrus

p = 0.0002

1220

Inferior temporal gyrus (R)

59.56

− 7.57

− 28.66

4.51

0.05

Right parahippocampal gyrus

p = 0.0005

335

Parahippocampal gyrus (R)

15.12

− 12.79

− 11.08

4.82

0.02

Left lingual gyrus

p = 0.01

246

− 16.26

− 93.19

− 12.51

3.14

Right lingual gyrus

p = 0.02

311

10.08

− 72.09

− 4.17

4.03

Left precentral gyrus

p = 0.03

385

− 14.29

− 19.43

70.91

4.12

Left superior parietal lobule

p = 0.03

329

− 31.33

− 70.83

47.50

3.64

  1. Significance thresholds for vertices and clusters of contiguous vertices and are determined using Random Field Theory; corrected p-values are given. Due to some of the clusters being extensive, the coordinates (in MNI space) are given for either peak vertices for clusters featuring such peaks (labeled in hot colors on Fig. 3). For smaller clusters without peaks, average cluster coordinates are provided.