Figure 1
From: Rational design of a helical peptide inhibitor targeting c-Myb–KIX interaction
Binding mechanism of Myb32 to KIX38,40. (a) Myb32 is in equilibrium between a disordered and partially helical structure in the free form. (b) The N-terminal helical region of Myb32 (red) binds KIX by a conformational selection mechanism. (c) After binding, the C-terminal region (blue) forms a helical structure by an induced-fit mechanism.
