Table 3 Candidate miRNA-target gene pairs associated with AESD.

From: GWAS identifies candidate susceptibility loci and microRNA biomarkers for acute encephalopathy with biphasic seizures and late reduced diffusion

miRNA

Annotation in miRBase

Genes

Gene description NCBI reference sequences

hsa-mir-1272

Insufficient data

TNFRSF19

The encoded protein is a member of the TNF-receptor superfamily

hsa-mir-34c

High

GINS3

The encoded protein is essential for the initiation of DNA replication and replisome progression

hsa-mir-4448

Insufficient data

SCNM1

SCNM1 modifies phenotypic expression of SCN8A mutations

hsa-mir-449a

Insufficient data

ASB4

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins

GINS3

 

hsa-mir-449b

High

ASB4

 

GINS3

hsa-mir-449c

High

CLDN8

The encoded protein plays roles in maintaining cell polarity and signal transductions

hsa-mir-4782

Insufficient data

KCNIP1

This gene encodes a member of the family of cytosolic voltage-gated potassium channel-interacting proteins

hsa-mir-623

Insufficient data

KLHL20

Members of this family are present throughout the cell and extracellularly with diverse activities

  1. The enrichment of the pairwise association signals of miRNAs and their target genes was evaluated. The significance threshold of p-Gene and p-miRNA was α = 0.01.
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