Table 4 Metabolites characteristically detected in mouth-rinsed water.
Metabolite | Category | HMDBa | HMDB (saliva) | Dental calculus (GC–MS)15 | GCFb (GC–MS)16 | Tongue coating (NMR)17 |
|---|---|---|---|---|---|---|
Ethanolamine phosphate | Glycerophospholipid metabolite | 〇 | 〇 | 〇 |  |  |
Phosphorylcholine | Glycerophospholipid metabolites (tongue moss metabolites from tongue coating17) | 〇 | 〇 | 〇 |  | 〇 |
Fumarate | Dicarboxylic acids, microbial metabolites (Aspergillus) | 〇 | 〇 | 〇 |  |  |
3-Hydroxypropionate | Carboxylic acids, microbial metabolites (Escherichia, Klebsiella, Saccharomyces) | 〇 |  |  |  |  |
Diethanolamine | Glycerophospholipid metabolite | 〇 |  |  |  |  |
5-Oxoproline | Cyclic amino acids (spontaneous cyclization condensation of glutamic acid) | 〇 | 〇 | 〇 |  |  |
Malate | Dicarboxylic acid (GCF metabolite16) | 〇 | 〇 | 〇 | 〇 |  |
Pelargonate | C9 fatty acid | 〇 | 〇 | 〇 |  |  |
Malonate | Dicarboxylic acid | 〇 | 〇 | 〇 |  |  |
Adipate | Dicarboxylic acid | 〇 | 〇 | 〇 |  |  |
Phthalate | Aromatic dicarboxylic acid | 〇 | 〇 |  |  |  |
Allantoin | Microbial Metabolites (Bacillus, Streptomyces) | 〇 | 〇 | 〇 |  |  |
5-Methoxyindoleacetate | Indole acetic acid derivative (No report of detection in blood) | 〇 | 〇 |  |  |  |
10-Hydroxydecanoate | C10 fatty acids (without HMDB registration) | Â | Â | Â | Â | Â |
Dodecanedioate | Dicarboxylic acid (tartar metabolite15) | 〇 |  | 〇 |  |  |
