Figure 1

Retinal Phenotype of 12-Month-Old Tmem135^FUN025/+ mice. (A) Representative images of the retinas of 12-month-old WT, Tmem135^FUN025/+ (FUN025/+) and Tmem135^{FUN025/FUN025} (FUN025/FUN025) mice. Note the decreased ONL thickness and subretinal immune cell (denoted with a yellow asterisk) in the 12-month-old Tmem135^{FUN025/FUN025} retina which are not present in the 12-month-old Tmem135^FUN025/+ mice. Magnification = 20×. Scale bar = 100 microns. (B) ONLT and RPE ratios. No significant differences were noted between the WT and Tmem135^FUN025/+ mice. (C-G) ERG recordings for 12-month-old WT, Tmem135^FUN025/+ and Tmem135^{FUN025/FUN025} mice during scotopic and photopic conditions. ^* and ^** indicates a P < 0.05 and P < 0.01 significance by post hoc Tukey test following a significant difference detected by one-way ANOVA between WT and Tmem135^FUN025/+. ^#, ^##, ^###, and ^#### indicates a P < 0.05, P < 0.01, P < 0.001, and P < 0.0001significance by post hoc Tukey test following a significant difference detected by one-way ANOVA between WT and Tmem135^{FUN025/FUN025} mice. All data are mean ± s.e.m.