Figure 2
From: A mutation in transmembrane protein 135 impairs lipid metabolism in mouse eyecups
RNA-Seq analysis of 2.5-month-old heterozygous and homozygous Tmem135 mutant eyecups compared to WT eyecups. Volcano plot highlighting differentially-expressed genes with fold changes greater than 2 that reach statistical significance (p < 0.05) between (A) Tmem135FUN025/+ (FUN025/+) and WT eyecups as well as (B) Tmem135FUN025/FUN025 (FUN025/FUN025) and WT eyecups. Genes that are upregulated and downregulated are highlighted in magenta and cyan, respectively. Gene Set Enrichment Analysis (GSEA) results of significantly enriched gene sets (FDR < 0.01) of (C) downregulated genes and (D) upregulated in Tmem135FUN025/+ and Tmem135FUN025/FUN025 eyecups compared to WT eyecups. The numbers within brackets indicate the number of genes in the leading edge in the gene set and the colour indicates the normalized enrichment score where the lighter tone means less enrichment and darker tone means more enrichment.
