Figure 4
From: A mutation in transmembrane protein 135 impairs lipid metabolism in mouse eyecups
Correlation analysis highlights important signalling pathways affected by Tmem135 mutations. Heatmap of genes which are significantly (A) positively and (B) negatively correlated (FDR < 0.01) with the number of mutant Tmem135 alleles in 2.5-month-old WT, Tmem135FUN025/+, and Tmem135FUN025/FUN025 eyecups. Signalling network highlights interactions of (C) BCL6 corepressor (Bcor), (D) non-canonical polycomb recessive complex 1 (PRC1), and (E) isocitrate dehydrogenase 1 (Idh1). Network generated using the SIGnalling Network Open Resource (SIGNOR 2.0).
