Figure 5
From: A mutation in transmembrane protein 135 impairs lipid metabolism in mouse eyecups
Lipid Levels in WT, Heterozygous and Homozygous Tmem135 Mutant Eyecups. Cholesterol levels in eyecups of (A) 3-month-old and (B) 12-month-old WT, Tmem135FUN025/+ (FUN025/ +), and Tmem135FUN025/FUN025 (FUN025/FUN025) mice. * indicates a P < 0.05 significance by post hoc Tukey test following a significant difference detected by one-way ANOVA. Numbers with brackets denote number of mice used for experiment. Each dot represents each individual sample. Data is presented as mean ± s.d.. (C) Representative RPE flat mount images after labelling for tight junctions (green) and staining for neutral lipids (red) and nuclei (blue). Mag = 20×, Scale Bar = 25 microns.
