Figure 7
From: A mutation in transmembrane protein 135 impairs lipid metabolism in mouse eyecups
Comparison of Tmem135FUN025/FUN025 eyecup and AMD-afflicted RPE/choroid transcriptional profiles. (A) Heatmap showing the significantly altered genes from Tmem135FUN025/FUN025 vs. WT which are affected in a similar direction (up [magenta] or down [cyan]) when compared with integrated expression analysis from microarray and RNA-Seq data (GSE29801 and GSE135092) from AMD patients. Genes which are affected in *intermediate and #advanced stage of AMD are also highlighted. (B) Signalling network highlights interactions of Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1). Network generated using the SIGnalling Network Open Resource (SIGNOR 2.0).
