Table 1 Pathway analysis using Gene Set Enrichment Analysis on Tmem135FUN025/+ and Tmem135FUN025/FUN025 compared to WT gene sets*.
From: A mutation in transmembrane protein 135 impairs lipid metabolism in mouse eyecups
Description | Tmem135FUN025/+ vs WT | Tmem135FUN025/FUN025 vs WT | ||
|---|---|---|---|---|
NES | FDR | NES | FDR | |
WP4346: Cholesterol metabolism | Â | Â | 2.71 | 0 |
mmu01212: Fatty acid metabolism | Â | Â | 2.53 | 0 |
GO:0,008,202: Steroid metabolic process | Â | Â | 2.33 | 0.0023 |
mmu04721: Synaptic vesicle cycle | − 1.78 | 0.0225 | − 1.88 | 0.0058 |
GO:0,050,953: Sensory perception of light stimulus | − 2.11 | 0.0009 | − 1.97 | 0.0141 |
mmu05012: Parkinson disease | − 2.17 | 0 | − 2.01 | 0.0012 |
mmu03010: Ribosome | − 2.21 | 0 | − 2.03 | 0.0018 |
GO:0,043,292: Contractile fiber | − 2.22 | 0 | − 2.06 | 0 |
GO:0,044,455: Mitochondrial membrane part | − 2.13 | 0 | − 2.1 | 0 |
