Table 2 Summary of significantly-affected genes in common between Tmem135FUN025/FUN025 versus WT eyecup RNAseq and GSE29801 and GSE135092 datasets.
From: A mutation in transmembrane protein 135 impairs lipid metabolism in mouse eyecups
Stage of AMD | Genes in Common Between Tmem135FUN025/FUN025 eyecups and AMD-afflicted RPE/choroid samples | |
|---|---|---|
Downregulated | Upregulated | |
Mixed | Samd11, Gata2, Ddt, Cyb5a, Des, Procr, Galnt9, Arpp21, Ramp2 | Chrnb4, Srebf1, Fasn, Acat2, Fads1, Fads2, Col8a1, Lss, Cd109, Bmp8b, Hmgcs1, Msmo1, Arhgap32, Mpv17l, Eif5a2, Insig1 |
Intermediate | Cyb5a | Chrnb4, Srebf1, Fasn, Acat2, Col8a1, Lss |
Advanced | Gata2, Cyb5a | Srebf1, Lss |
