Figure 1 | Scientific Reports

Figure 1

From: Pterostilbene downregulates BCR/ABL and induces apoptosis of T315I-mutated BCR/ABL-positive leukemic cells

Figure 1

Flow cytometric measurement of apoptosis induced by pterostilbene in various leukemic cell lines, normal hematopoietic progenitor/stem cells, and primary leukemic samples. (a) Measurement of cell apoptosis in the presence of a control vehicle (v) or pterostilbene (p). *P < 0.01, **P < 0.001, ***P < 0.0001 compared with the vehicle. Values represent the mean ± SD of triplicate samples. #Apoptosis was induced by pterostilbene in a significantly higher percentage of BCR/ABL+ leukemic cells than in BCR/ABL− leukemic cells (P < 0.01). (b) Measurement of cell apoptosis in the presence of vehicle, dasatinib or pterostilbene. **P < 0.001, ***P < 0.0001 compared with the vehicle. ****P < 0.0001 compared with the vehicle or dasatinib. Values represent the mean ± SD of triplicate samples. (c) Measurement of cell apoptosis in primary leukemic samples. **P < 0.001, ***P < 0.0001 compared with the vehicle. Values represent the mean ± SD of triplicate samples.

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