Figure 1

Coagulation profile of COVID-19 convalescent plasma (purple), pathogen reduced COVID-19 convalescent plasma (green), and standard fresh frozen plasma (yellow). The following measurements were made: prothrombin time (PT, s), activated partial thromboplastin time (aPTT, s), thrombin time (TT, s), fibrinogen (FGN, mg/dL), D-Dimer (D-D, ng/dL fibrinogen equivalent units [FEU]), von Willebrand factor (vWF) activity (%), von Willebrand factor antigen (%), various coagulation factors II, V, VII–XII (FII, FV, FVII–FXII, %), protein S (PS) activity (%), protein C (PC) antigen (%), and alpha-2 plasmin inhibitor (a2-PI, %). Individual data are represented as symbols and summary statistics (mean ± standard deviation [SD]) are represented as bar charts. Grouped data are compared using one-way analysis of variance with Tukey’s honestly significant difference (HSD) post hoc test to determine p values; *p < 0.05; **p < 0.01; and ***p < 0.001). Horizontal bars above given columns indicate the comparisons being made. Whole blood reference ranges are denoted by grey filled areas bound by dotted black lines. Reference ranges are not available for FGN, FV:C, FVIII:C, and PC antigen.