Table 2 Coagulation profile of three preparations of human plasma, COVID-19 convalescent plasma, pathogen-reduced COVID-19 convalescent plasma, and fresh frozen plasma.

Variable	Convalescent plasma	Pathogen-reduced convalescent plasma	Fresh frozen plasma	p values
PT (s)	11.7 ± 0.5	12.4 ± 0.9	12.1 ± 1.0	^ns, ^ns, ^ns
aPTT (s)	29.3 ± 2.6	33.5 ± 2.4	29.1 ± 2.4	*^, ^ns, *
TT (s)	22.8 ± 1.4	27.6 ± 2.1	23.8 ± 1.9	*^, ^ns, *
FGN (mg/dL)	282 ± 39	228 ± 41	282 ± 56	*^, ^ns, *
D-D (ng/mL FEU)	283 ± 130	259 ± 79	297 ± 155	^ns, ^ns, ^ns
vWF activity (%)	86 ± 26	85 ± 25	100 ± 34	^ns, ^ns, ^ns
vWF antigen (%)	104 ± 33	101 ± 31	115 ± 39	^ns, ^ns, ^ns
FII:C (%)	99 ± 11	87 ± 8	92 ± 13	*^, ^ns, ^ns
FV:C (%)	100 ± 21	82 ± 18	94 ± 16	*^, ^ns, ^ns
FVII:C (%)	98 ± 22	102 ± 23	90 ± 26	^ns, ^ns, ^ns
FVIII:C (%)	113 ± 34	51 ± 14	132 ± 33	*^, ^ns, *
FIX:C (%)	105 ± 17	79 ± 10	112 ± 23	*^, ^ns, *
FX:C (%)	95 ± 12	79 ± 13	88 ± 17	**^, ^ns, ^ns
FXI:C (%)	117 ± 23	80 ± 12	109 ± 18	*^, ^ns, *
FXII:C (%)	111 ± 20	79 ± 24	103 ± 22	*^, ^ns, *
PS activity (%)	109 ± 14	75 ± 22	105 ± 20	*^, ^ns, *
PC antigen (%)	90 ± 15	86 ± 12	74 ± 21	^ns, *^, ^ns
a2-PI (%)	113 ± 8	86 ± 6	108 ± 10	*^, ^ns, *

The following measurements were made: prothrombin time (PT, seconds), activated partial thromboplastin time (aPTT, seconds), thrombin time (TT, seconds), fibrinogen (FGN, mg/dL), D-Dimer (D-D, ng/dL fibrinogen equivalent units [FEU]), von Willebrand factor (vWF) activity (%), von Willebrand factor antigen (%), various coagulation factors II, V, VII–XII (FII:C, FV:C, FVII:C–FXII:C, %), protein S (PS) activity %), protein C (PC) antigen (%), and alpha-2 plasmin inhibitor (a2-PI, %). Data are reported as mean ± standard deviation (SD) and compared using one-way analysis of variance with Tukey’s honestly significant difference (HSD) post hoc test to determine p values. p values (ns, p > 0.05; *p < 0.05; **p < 0.01; and ***p < 0.001) are reported in the order of the following comparisons: convalescent plasma to pathogen-reduced convalescent plasma, convalescent plasma to fresh frozen plasma, and pathogen-reduced convalescent plasma to fresh frozen plasma.

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