Figure 1

Haemotoxylin and eosin images showing spectrum of inflammation in high grade muscle invasive urothelial carcinoma. (A) Low power image showing carcinoma-stroma interface with high invasive front inflammation (black arrows indicate invading carcinoma, white arrows the stroma), (B) low power image with minimal invasive front inflammation (black arrows highlight areas of carcinoma), (C) well defined lymphoid structure with germinal centre in keeping with a tertiary lymphoid structure (indicated by black arrow), (D) loose collection of lymphocytes comprising a lymphoid aggregate (indicated by black arrow).