Figure 8 | Scientific Reports

Figure 8

From: Dissecting the interaction between HSP70 and vascular contraction: role of \(\hbox{Ca}^{2+}\) handling mechanisms

Figure 8

Proposed mechanism of HSP70 in aorta stimulated with phenylephrine. Pharmacological blockade of HSP70 modulates \(\hbox {Ca}^{2+}\) handling mechanisms in aorta stimulated with phenylephrine potentially via crosstalk with (a) IP3r-mediated \(\hbox {Ca}^{2+}\) release from the SR (phasic) and (b) voltage-independent \(\hbox {Ca}^{2+}\) channels-facilitated \(\hbox {Ca}^{2+}\) influx (tonic). Created with BioRender.com.

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