Figure 2
From: Chronic BDNF simultaneously inhibits and unmasks superficial dorsal horn neuronal activity
Effect of gap junction blocker octanol on BDNF-induced [Ca2+]I fluctuations. (A) Scatterplot summarizing the effects of octanol on mean fluctuation amplitude and examples of FIBSI-processed recordings. The two bottom recordings show a decrease in fluctuation amplitude and the two top show an increase. (B–D) Neurons were sorted based on whether they exhibited a positive or negative fold change in mean fluctuation amplitude in response to octanol. Paired analyses showed octanol selectively and significantly decreased the mean fluctuation frequency, increased the mean fluctuation duration, and decreased the mean fluctuation rise time (i.e., more negative peak time) in the neurons with positive fold changes in mean fluctuation amplitude. Control vs octanol paired comparisons for the groups in (B–D) were made using two-way repeated measures ANOVAs and Sidak’s post-hoc test. **P < 0.01, ****P < 0.0001.
