Table 3 Correlations between percentage change in small fibre pathology and other measures of diabetic neuropathy from baseline to follow up.

From: Corneal confocal microscopy identifies small fibre damage and progression of diabetic neuropathy

Variable

CNBD

CNFD

CNFL

IENFD

IENFD

r = 0.53

p = 0.02

r = 0.62

p = 0.005

r = 0.56

p = 0.01

 

NSP

r = − 0.26

p = 0.29

r = − 0.43

p = 0.08

r = − 0.045

p = 0.86

r = − 0.07

p = 0.76

NDS

r = − 0.13

p = 0.58

r = − 0.43

p = 0.08

r = − 0.11

p = 0.66

r = − 0.05

p = 0.82

CPT

r = 0.076

p = 0.77

r = 0.29

p = 0.26

r = 0.66

p = 0.006

r = 0.27

p = 0.26

VPT

r = − 0.55

p = 0.02

r = − 0.54

p = 0.03

r = − 0.08

p = 0.76

r = − 0.12

p = 0.37

DB-HRV

r = − 0.19

p = 0.42

r = − 0.55

p = 0.02

r = − 0.14

p = 0.57

r = − 0.03

p = 0.87

LFA/RFA ratio

r = 0.26

p = 0.27

r = 0.09

p = 0.70

r = 0.017

p = 0.95

r = 0.13

p = 0.58

E/I ratio

r = 0.24

p = 0.32

r = 0.31

p = 0.21

r = 0.68

p= 0.002

r = 0.595

p= 0.007

Valsalva ratio

r = 0.41

p = 0.08

r = 0.14

p = 0.56

r = 0.25

p = 0. 32

r = 0.59

p= 0.008

  1. NSP—neuropathy symptom profile, NDS—neuropathy disability score, DNS—diabetic neuropathy symptom score, VPT—vibration perception threshold, CPT—cold perception threshold, DB-HRV—deep breathing heart rate variability, LFA/RFA ratio—low frequency area (sympathetic) and high frequency area (parasympathetic) ratio, E/I—expiration/inspiration ratio, CNFD—corneal nerve fibre density, CNBD—corneal nerve branch density, CNFL—corneal nerve fibre length, IENFD—intraepidermal nerve fibre density. Bold values show statistically significant results.