Table 3 Comparison of clinical characteristics, and contents of treatment between survivors and non-survivors in MPA with ILD.

From: Evaluation of poor prognostic factors of respiratory related death in microscopic polyangiitis complicated by interstitial lung disease

Characteristics

Survivors (n = 35)

Non-survivors (n = 12)

P value

Age, years

73 (70–78)

78 (71–86)

0.236

Female, n (%)

20 (57.1)

4 (33.3)

0.193

Disease duration, months

2 (0–36)

19 (0–42)

0.485

Smoking history, n (%)

21 (60.0)

6 (50)

0.737

DAH, n (%)

5 (14.3)

2 (16.7)

1.000

Laboratory findings

WBC, /mm3

10,470 (7000–14,900)

12,110 (7903–13,663)

0.932

Hb, g/dL

10.3 (8.6–12.2)

10.7 (8.8–12.8)

0.678

Alb, g/dL

2.9 (2.3–3.3)

2.4 (2–3.4)

0.348

LD, IU/L

206 (167–262)

186 (145–243)

0.373

Cr, mg/dL

0.9 (0.7–1.34)

1.1 (0.7–1.7)

0.49

CRP, mg/mL

7.9 (3.0–12.2)

9.7 (2.3–14.0)

0.393

MPO-ANCA titer, U/mL

95.2 (49.5–235.1)

62.3 (36.0–239.5)

0.51

KL-6, U/mL

371 (245–626)

415 (240.3–675.3)

0.696

PaO2/FiO2 ratio

406.7 (352.9–441.9)

396.2 (341.5–433.3)

0.733

PFT findings

%FVC

91.9 (79.9–96.1)a

73.4 (66.6–79.6)b

0.0078**

FEV1/FVC

81.0 (77.0–86.2)a

86.3 (78.3–91.7)b

0.163

%Dlco, ml/min/mmHg

43.5 (34.9–51.5)c

31.4 (24.2–57.1)d

0.39

Chest HRCT score

GGO score

Right upper lobe

0.66 (0.33–1.33)

1.33 (0.75–2)

0.068

Right middle lobe

0.33 (0–0.67)

0.83 (0.08–1)

0.219

Right lower lobe

1.67 (1.33–2)

2 (2–2.83)

0.082

Left upper lobe

0.66 (0–1.3)

1 (1–1.92)

0.082

Left lower lobe

1.33 (0.66–2)

1.66 (1.08–2)

0.396

Total

4.98 (2.99–7.64)

6.66 (5.17–8.66)

0.047*

Fibrosis score

Right upper lobe

0.66 (0.33–1.33)

1 (0.66–1.66)

0.149

Right middle lobe

0 (0–0.66)

0.66 (0.33–1)

0.041*

Right lower lobe

1.33 (1–1.66)

2 (1.66–2.25)

0.0019**

Left upper lobe

0.66 (0.33–1.33)

1 (0.66–1.66)

0.283

Left lower lobe

1.33 (0.66–1.66)

1.83 (1.33–2)

0.024*

Total

4 (2.98–6.65)

6.16 (5.32–8.81)

0.016*

  1. The laboratory markers are presented as the median (interquartile range). The P-values were estimated using Fisher’s exact test or Wilcoxon rank sum test.
  2. MPA microscopic polyangiitis, ILD interstitial lung disease, DAH diffuse alveolar hemorrhage, WBC white blood cell, Hb hemoglobin, Alb albumin, LD lactate dehydrogenase, Cr creatinine, CRP C-reactive protein, MPO-ANCA myeloperoxidase-anti-neutrophil cytoplasmic autoantibody, KL-6 Krebs von den Lungen-6, PaO2/FiO2 ratio arterial partial pressure of O2 and the fraction of inspired oxygen ratio, PFT pulmonary function test, FVC forced vital capacity, FEV forced expiratory volume in one second, Dlco diffusing capacity of the lung for carbon monoxide, HRCT high resolution computed tomography, GGO ground-glass opacity.
  3. *P < 0.05, **P < 0.01.
  4. aNumber of subjects, n = 26.
  5. bNumber of subjects, n = 11.
  6. cNumber of subjects, n = 25.
  7. dNumber of subjects, n = 9.
Back to article page