Table 3 Cox regression analysis for the risk of mortality according to the TCO2 category groups.

From: Low serum total CO2 and its association with mortality in patients being followed up in the nephrology outpatients clinic

Outcome

Model

Group

HR

95% CI

P value

Mortality

1

Low versus normal

2.231

(2.084, 2.389)

 < 0.001

High versus normal

0.623

(0.567, 0.685)

 < 0.001

2

Low versus normal

1.967

(1.836, 2.107)

 < 0.001

High versus normal

0.661

(0.601, 0.726)

 < 0.001

3

Low versus normal

1.472

(1.366, 1.585)

 < 0.001

High versus normal

0.715

(0.650, 0.786)

 < 0.001

4

Low versus normal

1.484

(1.377, 1.599)

 < 0.001

High versus normal

0.713

(0.649, 0.785)

 < 0.001

5

Low versus normal

1.481

(1.375, 1.595)

 < 0.001

High versus normal

0.713

(0.649, 0.784)

 < 0.001

  1. Model 1: TCO2 only.
  2. Model 2: Model 1 + sex, age, history of hypertension and diabetes.
  3. Model 3: Model 2 + baseline kidney function as MDRD-GFR.
  4. Model 4: Model 3 + usage of sodium bicarbonate.
  5. Model 5: Model 4 + RAAS blockades + Diuretics group.
  6. Group definition: Low group, < 22 mEq/L versus Normal group, 22–29 mEq/L versus High group, ≥ 30 mEq/L.
  7. CI confidence interval, ESRD end-stage renal disease, GFR glomerular filtration rate, HR hazard ratio, MDRD modification of diet in renal disease, TCO2 total CO2.
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