Table 1 Comparison of commercial sterilization technologies that use vaporized and ionized hydrogen peroxide.

Bioquell

Bioquell Clarus C; Bioquell Z-2; Bioquell ProteQ

HPV

Hydrogen Peroxide Vapor

30–35% liquid H₂O₂ vaporized and delivered into a chamber; saturated H₂O₂ condenses on surfaces^6,14,15,18

EUA granted (3/28/2020) to Batelle to use Bioquell as part of its Critical Care Decontamination System for up to 20 cycles of N95 mask reuse³⁹

Steris Corporation

STERIS V-PRO 1 Plus, maX and maX2 Low Temperature Sterilization Systems

VHP

Vaporized Hydrogen Peroxide

30–35% liquid H₂O₂ is vaporized and delivered into a dehumidified chamber; concentration is held below condensation point¹⁶

EUA granted (4/10/2020) to Steris Corporation for STERIS V-PRO 1 Plus, maX and maX2 Low Temperature Sterilization Systems for up to 10 cycles of single-user reuse⁴⁰

Advanced Sterilization Products (ASP)

STERRAD 100S H₂O₂ Gas Plasma Sterilizer; STERRAD NX H₂O₂ Gas Plasma Sterilizer; STERRAD 100NX H₂O₂ Gas Plasma Sterilizer

HPGP

Hydrogen Peroxide Gas Plasma

58–60% liquid H₂O₂ is vaporized into a chamber; radiation frequency energy is targeted into the chamber, exciting the H₂O₂ to a low-temperature plasma state^7,21

EUA granted (4/12/2020) to ASP for STERRAD 100S Cycle, STERRAD NX Standard Cycle, or STERRAD 100NX Express Cycle for up to two cycles in Tyvek pouching for single-user reuse³⁸

TOMI

SteraMist Binary Ionization Technology (BIT)

iHP

Ionized Hydrogen Peroxide

7.8% aqueous H₂O₂ aerosolized. 0.05–3 µm droplets are pushed past a cold plasma field generated by two electrodes and ionized into hydroxyl radicals⁴¹

The topic of this study. Currently being investigated for sterilization of PPE for re-use in academic medical centers