Figure 2 | Scientific Reports

Figure 2

From: Increased colonic K+ excretion through inhibition of the H,K-ATPase type 2 helps reduce plasma K+ level in a murine model of nephronic reduction

Figure 2

Parameters of the K+ balance. The absence of HKA2 limits the increase of plasma K+ level. (A) Daily K+ intake in sham WT (white circles), sham HKA2KO (black circles), N5/6 WT (white squares) and N5/6 HKA2KO (black squares) mice. Results are shown as the mean ± s.e.m. Numbers in italic = n of mice. (B) Daily urine K+ excretion in sham WT (white circles), sham HKA2KO (black circles), N5/6 WT (white squares) and N5/6 HKA2KO (black squares) mice. Results are shown as the mean ± s.e.m. Numbers in italic = n of mice. (C) Daily fecal K+ excretion in sham WT (white circles), sham HKA2KO (black circles), N5/6 WT (white squares) and N5/6 HKA2KO (black squares) mice. Results are shown as the mean ± s.e.m. Numbers in italic = n of mice. Two-way ANOVA test followed by a Sidak’s multiple comparisons test, (**p < 0.01; *p < 0.05). D/ Plasma K+ value in sham WT (white circles), sham HKA2KO (black circles), N5/6 WT (white squares) and N5/6 HKA2KO (black squares) mice. Results are shown as the mean ± s.e.m. Numbers in italic = n of mice. Two-way ANOVA test followed by a Sidak’s multiple comparisons test, (**p < 0.01; *p < 0.05).

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