Figure 5 | Scientific Reports

Figure 5

From: Increased colonic K+ excretion through inhibition of the H,K-ATPase type 2 helps reduce plasma K+ level in a murine model of nephronic reduction

Figure 5

Enalapril-induced hyperkalemia is lowered in N5/6 HKA2KO mice. (A) Daily K+ intake in N5/6 WT (circles) or HKA2KO (squares) mice after 24 h-K+ loading treated (grey symbols) or not (white symbols) with enalapril (0.12 mg/ml) for a week. (B) Fecal K+ excretion in N5/6 WT (circles) or HKA2KO (squares) mice after 24 h-K+ loading, treated (grey symbols) or not (white symbols) with enalapril (0.12 mg/ml) for a week. (C) Plasma K+ values in N5/6 WT (circles) or HKA2KO (squares) mice after 24 h-K+ loading, treated (grey symbols) or not (white symbols) with enalapril (0.12 mg/ml) for a week. Results are shown as the mean ± s.e.m (n = 10). Two-way ANOVA test followed by a Sidak’s multiple comparisons test, (**p < 0.01; *p < 0.05).

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