Table 1 Physiological parameters of WT or HKA2KO mice, sham or nephrectomised (N5/6) under normal (NK) or high potassium (2% KCl) diet for 24 h.

From: Increased colonic K+ excretion through inhibition of the H,K-ATPase type 2 helps reduce plasma K+ level in a murine model of nephronic reduction

 

NK

2% KCl

WT

HKA2KO

WT

HKA2KO

Sham

N5/6

Sham

N5/6

Sham

N5/6

Sham

N5/6

Weight (g)

25.3 ± 0.9

22.8 ± 0.6

26.2 ± 1.0

24.6 ± 0.5

25 ± 0.9

21.6 ± 0.6

25.5 ± 0.9

23.8 ± 0.4

Food (g)

3.2 ± 0.4

3.7 ± 0.1

4.0 ± 0.2

3.9 ± 0.2

3.8 ± 0.2

2.5 ± 0.1**

4.2 ± 0.3

2.3 ± 0.1**

Water (ml)

3.8 ± 0.2

6.8 ± 0.6*

3.8 ± 0.3

7.9 ± 0.5**

5.6 ± 1.3

6.2 ± 0.6

5.2 ± 0.3

6,7 ± 0.8

Urine vol. (ml)

1.2 ± 0.2

2.6 ± 0.4*

1.5 ± 0.2

3.7 ± 0.4**##

1.8 ± 0.2

4.2 ± 0.3**

2.5 ± 0.3

4.4 ± 0.4**

Feces (g/day)

1.3 ± 0.1

1.4 ± 0.1

1.7 ± 0.2#

1.4 ± 0.1

1.0 ± 0.1

0.8 ± 0.1

1.5 ± 0.1

0.8 ± 0.1

Plasma creat. (mM)

11.4 ± 0.6

21.1 ± 1.0**

8.5 ± 0.7

25.3 ± 2.2**

N.D

N.D

N.D

N.D

  1. Results are shown as mean ± s.e.m. Two-way ANOVA test followed by a Sidak’s multiple comparisons test, (sham vs N5/6 **p < 0.01; *p < 0.05—WT vs. HKA2KO ##p < 0.01; #p < 0.05).
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