Figure 5
Transfection of LV-CGRP restored TRPV1 without alteration of SP and NGF. Transfection of LV-CGRP in the DRG neurons from diabetic animals completely restored TRPV1 coding mRNA (A) and TRPV1 (B,C) while no alteration was detected in SP (D,E) and NGF (F,G). Control the neurons from the age matched non-diabetic animals, Diabetic the neurons from the diabetic animals, Db + LV-GFP DRG neurons from diabetic animals transfected with GFP genes, Db + LV-CGRP DRG neurons from diabetic animals transfected with CGRP genes. *p < 0.05, compared to the control; **p < 0.01, compared to the control; $$p < 0.01, compared to diabetic group; &&p < 0.01, compared to Db + LV-GFP group.
