Figure 2

(a) Univariate Cox regression analysis showing that the factors related to ACLF prognosis were age, WGO type, basic etiology, bacterial infection, ascites, gastrointestinal bleeding, hepatic encephalopathy stage, glutamate transpeptidase, albumin, total bilirubin, cholinesterase, prothrombin activity, blood urea nitrogen, creatinine, serum sodium, neutrophil ratio, and platelets. (b), Multivariate Cox regression analysis confirmed that age, WGO type, alcoholic etiology, total bilirubin, creatinine, prothrombin activity, and hepatic encephalopathy stage remained associated with prognosis of ACLF. (Assignment of indexes in COX regression analysis was as follows: WGO type A, B, and C of ACLF were assigned 1, 2, and 3 respectively; basic etiology was assigned 1 for the alcoholic liver disease alone, and 0 for others; positive complications including bacterial infection, gastrointestinal bleeding, ascites were all assigned 1, no complications 0; hepatic encephalopathy was assigned 0, 1, 2, 3, and 4 according to the West Haven stages 0, I, II, III, and IV, respectively; artificial liver system support (ALSS) was assigned 1, no ALSS 0).